Rosa Bacchetta

This study identifies the epigenetic signature and key transcription factors regulating human antigen-specific Tr1 cells, revealing their unique biology and potential for therapeutic applications.

FOXP3-engineered regulatory T cells enhance intestinal barrier function in Crohn's disease enteroids via the PDGF-AA-PDGFR axis, independent of their immunosuppressive role.

The paper identifies CXCR6⁺ CD127⁻ Tr1 cells as key regulators in Plasmodium falciparum infection, showing they balance immunity and parasite persistence.

This study identifies an epigenetic signature at the FOXP3 distal enhancer in Kabuki syndrome patients that impairs Treg development, linking KMT2D loss to immune dysregulation.

This paper develops a non-viral CRISPR-Cas9 system for precise genome editing in human T cells, enabling therapeutic reprogramming of cell function and specificity.