Dysregulated coordination of MAPT exon 2 and exon 10 splicing underlies different tau pathologies in PSP and AD
Kathryn R. Bowles, Derian A. Pugh, Laura‐Maria Oja, Benjamin M. Jadow, Kurt W. Farrell, Kristen R. Whitney, Abhijeet Sharma, Jonathan D. Cherry, Towfique Raj, Ana C. Pereira, John F. Crary, Alison Goate
The paper identifies dysregulated coordination of MAPT exon 2 and exon 10 splicing in Alzheimer's and progressive supranuclear palsy, leading to distinct tau isoform accumulation.
Acta Neuropathologica · Dec 7, 2021Peer-reviewedNeuroscience