Author

Derian A. Pugh

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:Drosophila· 1

Frequent Co-Authors

Alison GoateiD· 4 shared Kathryn R. BowlesiD· 4 shared John F. CraryiD· 3 shared Celeste M M. KarchiD· 2 shared Jonathan D. CherryiD· 2 shared Kristen R. WhitneyiD· 2 shared Towfique RajiD· 2 shared Abhijeet SharmaiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersNeuroscience

Alison GoateORCID

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Author profile →

5 papers

Recent·Most cited

Alternative Anastrozole Target CYP4V2 Impairs Neurons in Preclinical Models of Inherited Tauopathy

Chiara Pedicone, Sarah A. Weitzman, Joshua Orrick, Derian A. Pugh, Alison Goate, Ross Leigh Cagan, Kathryn R. Bowles, Masahiro Sonoshita

This study identifies anastrozole's off-target CYP4V2 as a neuroprotective factor in tauopathy models by reducing Tau phosphorylation and oxidative stress.

bioRxiv · Nov 29, 2025 · PreprintNeuroscience

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinsons disease are associated with LRRC37A/2 expression in astrocytes

Kathryn R. Bowles, Derian A. Pugh, Yiyuan Liu, Tulsi Patel, Alan Edward Renton, Sara Bandrés‐Ciga, Ziv Gan‐Or, Peter Heutink, Ari Siitonen, Sarah E. Bertelsen, Jonathan D. Cherry, Celeste M M. Karch, Steven J. Frucht, Brian Harris Kopell, Inga Peter, , Alison Goate

The paper identifies three H1 sub-haplotypes at the 17q21.31 locus associated with Parkinson's disease risk and links them to LRRC37A/2 expression in astrocytes.

Molecular Neurodegeneration · Jul 15, 2022Peer-reviewedNeuroscience

Integrated Proteomics Identifies Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer's Disease

Cheyenne D. Hurst, Derian A. Pugh, Measho H. Abreha, Duc Minh Duong, Eric B. Dammer, David Alan Bennett, Jeremy H. Herskowitz, Nicholas T. Seyfried

The paper identifies NRN1 as a mediator of cognitive resilience to Alzheimer's disease through integrative proteomic analysis and functional validation in neurons.

bioRxiv · Jun 15, 2022 · PreprintNeuroscience

Dysregulated coordination of MAPT exon 2 and exon 10 splicing underlies different tau pathologies in PSP and AD

Kathryn R. Bowles, Derian A. Pugh, Laura‐Maria Oja, Benjamin M. Jadow, Kurt W. Farrell, Kristen R. Whitney, Abhijeet Sharma, Jonathan D. Cherry, Towfique Raj, Ana C. Pereira, John F. Crary, Alison Goate

The paper identifies dysregulated coordination of MAPT exon 2 and exon 10 splicing in Alzheimer's and progressive supranuclear palsy, leading to distinct tau isoform accumulation.

Acta Neuropathologica · Dec 7, 2021Peer-reviewedNeuroscience

Glutamatergic dysfunction precedes neuron loss in cerebral organoids with MAPT mutation.

Kathryn R. Bowles, M. Catarina Silva, Kristen R. Whitney, Taylor B. Bertucci, Jacob C. Garza, Nathan C. Boles, Kevin H. Strang, Sidhartha K. Mahali, Jacob A. Marsh, Cynthia Chen, Derian A. Pugh, Yiyuan Liu, Joshua E. Berlind, Jesse D. Lai, Susan K. Goderie, , Sally Temple

This study shows that glutamatergic dysfunction occurs before neuron loss in cerebral organoids with MAPT mutations, suggesting therapeutic targets for FTD.

bioRxiv · Feb 3, 2021 · PreprintNeuroscience