Aberrant medial prefrontal cortex activity and flexible behavior in the TgF344-AD rat model of Alzheimer's disease
T. Joseph Sloand, Benjamin P. Dunham, Mark S. Niedringhaus, Elizabeth A. West
This study investigates cognitive deficits in TgF344-AD rats, finding impaired learning and flexible behavior linked to altered medial prefrontal cortex activity during reward prediction and outcome devaluation.
Journal of Neuroscience · Jan 13, 2026Peer-reviewedNeuroscience