Mathieu E. Wimmer

Early resource scarcity drives persistent transcriptional changes and vascular remodeling in the female prefrontal cortex

This study identifies female-specific vascular transcriptional changes and structural remodeling in the adult mPFC following early resource scarcity using snRNAseq and 3D vascular reconstruction.

Connecting self-report and instrumental behavior during incubation of food craving in humans.

This study develops a human paradigm to measure food craving incubation by linking self-reports with instrumental behavior, showing non-linear relationships over time.

Early resource scarcity causes cortical astrocyte enlargement and sex-specific changes in the orbitofrontal cortex transcriptome in adult rats

This study shows that early resource scarcity in rats increases astrocyte size in the orbitofrontal cortex and causes sex-specific transcriptome changes, affecting glutamatergic signaling.

Paternal morphine exposure enhances morphine self-administration and induces region-specific neural adaptations in reward-related brain regions of male offspring

This study shows that paternal morphine exposure increases morphine self-administration in male offspring but not females, with region-specific neural changes in reward-related brain areas.

Set2-mediated alternative splicing of Srsf11 regulates cocaine reward behavior

This study shows that Set2-mediated H3K36me3 regulates alternative splicing of Srsf11, which influences cocaine reward behavior in mice.

Chronic paternal morphine exposure increases sensitivity to morphine-derived antinociception

This study shows that chronic paternal morphine exposure increases offspring sensitivity to morphine's antinociceptive effects in a rat model.

CREB is Required in Excitatory Neurons in the Forebrain to Sustain Wakefulness

This study shows that CREB is necessary in forebrain neurons for maintaining wakefulness but not in the locus coeruleus.