A three-dimensional ex vivo model recapitulates in vivo features and unravels increased drug resistance in childhood acute lymphoblastic leukemia
Magdalini Kanari, Iria Jimenez Garcia, Fabio D. Steffen, Lisa A. Krattiger, Charles Bataclan, Wangjie Liu, Benjamin R. Simona, Bart Deplancke, Olaia Naveiras, Martin Ehrbar, Beat C. Bornhauser, Jean‐Pierre Bourquin
This paper develops a 3D ex vivo model of bone marrow to study childhood ALL, finding increased drug resistance in certain subtypes compared to 2D models.
Leukemia · Sep 10, 2025Peer-reviewedCancer Biology