Jean‐Pierre Bourquin

This study identifies TCF3::HLF's role in rewiring the 3D genome to drive leukemia by regulating MEF2C and altering hematopoietic stem cell gene expression.

Fractal introduces a task specification and platform for scalable, reproducible OME-Zarr-native bioimage analysis workflows, demonstrating reproducibility across diverse imaging data and clinical settings.

This study identifies how developmental maturity and fusion partner influence treatment response in KMT2A-rearranged B-ALL across all ages.

The paper identifies phospho-LCK (pY394) as a biomarker for dasatinib sensitivity in paediatric T-ALL using flow-cytometry, showing strong correlation with drug response.

This paper develops a 3D ex vivo model of bone marrow to study childhood ALL, finding increased drug resistance in certain subtypes compared to 2D models.

This study identifies treatment-resistant stem-like T-ALL cells that expand during relapse using single-cell RNA sequencing of pediatric T-ALL patient samples.

This paper introduces scNOVA, a method to analyze somatic structural variants in single-cell multiomics data, revealing their functional impacts on gene regulation and cancer pathways.

This paper introduces scTRIP, a method to detect structural variations in single cells, revealing new SV classes and mutational processes in cancer samples.