Antiparallel protocadherin homodimers use distinct affinity- and specificity mediating regions in cadherin repeats 1-4
John M. Nicoludis, Bennett E. Vogt, Anna G. Green, Charlotta P.I. Schärfe, Debora S. Marks, Rachelle Gaudet
The paper determines the structure of human PcdhYB3's antiparallel EC1-4 homodimer and shows that subfamily-specific specificity arises from loop region diversification, while EC1/EC4 interfaces use hydrophobic interactions for non-selective dimerization.
bioRxiv · Jul 12, 2016Biochemistry