Author

Charlotta P.I. Schärfe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein structure prediction· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Anna G. GreeniD· 2 shared Debora S. MarksiD· 2 shared Alexandre M.J.J. Bonvin· 1 shared Bennett E. Vogt· 1 shared Chris SanderiD· 1 shared João P.G.L.M. Rodrigues· 1 shared John M. Nicoludis· 1 shared Rachelle GaudetiD· 1 shared

Activity by Year

2014-2016 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

Anna G. GreenORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivJul 12, 2016

Antiparallel protocadherin homodimers use distinct affinity- and specificity mediating regions in cadherin repeats 1-4

John M. Nicoludis, Bennett E. Vogt, Anna G. Green…·Rachelle Gaudet

The paper determines the structure of human PcdhYB3's antiparallel EC1-4 homodimer and shows that subfamily-specific specificity arises from loop region diversification, while EC1/EC4 interfaces use hydrophobic interactions for non-selective dimerization.

DOI 10.7554/elife.18449

humanstructural biology

𝕏 PostBluesky

BioinformaticsbioRxivSep 15, 2014

Sequence co-evolution gives 3D contacts and structures of protein complexes

Thomas A. Hopf, Charlotta P.I. Schärfe, João P.G.L.M. Rodrigues…·Debora S. Marks

This paper uses sequence co-evolution to predict 3D contacts and structures of protein complexes, achieving accurate results on known structures and predicting contacts for unknown ones.

DOI 10.7554/elife.03430

protein sequencedeep learning

𝕏 PostBluesky