Rachelle Gaudet

The paper structures ZmaM, a type II peptidase-ABC transporter in B. cereus, showing it activates and exports zwittermicin A by coordinating peptidase and transporter modules.

The paper evaluates how protein fitness models predict and design variants with altered specificity, finding that models biased against such changes can be leveraged by using weighted differences in model scores.

The paper investigates the determinants of metal import and specificity in the bacterial transporter DraNramp by analyzing sequence variants and their effects on Mn2+ and Mg2+ import.

This study identifies clade B Nramps as proton-independent transition metal uniporters, suggesting proton coupling evolved later in Nramp evolution.

The paper quantifies surface delivery differences among clustered protocadherin isoforms and variants, revealing that cis dimerization is not tightly coupled to surface delivery.

The paper identifies yeast pheromone genes using computational filters, finding candidates in 238 out of 332 fungal genomes across 13 distant clades.

This study identifies a homozygous TRPV4 mutation as a cause of congenital spinal muscular atrophy and arthrogryposis through whole exome sequencing and functional analysis.

The paper determines the structure of human PcdhYB3's antiparallel EC1-4 homodimer and shows that subfamily-specific specificity arises from loop region diversification, while EC1/EC4 interfaces use hydrophobic interactions for non-selective dimerization.