Exploring Arylidene-Indolinone Ligands of Autophagy Proteins LC3B and GABARAP
Alexandria N. Leveille, Thomas Schwarzrock, Hawley Brown, Bennett True, Joanet Plasencia, Philipp Neudecker, Alina Üffing, Oliver H. Weiergräber, Dieter Willbold, Joshua A. Kritzer
The paper investigates the binding affinity of GW5074 to LC3B and GABARAP using an AlphaScreen assay, finding micromolar inhibitory potencies and suggesting potential for targeted protein degradation.
ACS Medicinal Chemistry Letters · Jan 6, 2025Peer-reviewedBiochemistry