Accurate de novo design of high-affinity protein binding macrocycles using deep learning
Stephen Rettie, David Juergens, Victor Adebomi, Yensi Flores Bueso, Qinqin Zhao, Alexandria N. Leveille, Andi Liu, Asim K. Bera, Joana Alessandra Wilms, Alina Üffing, Alex Kang, Evans Brackenbrough, Mila Lamb, Stacey Gerben, A G Murray, , Gaurav Bhardwaj
This paper introduces RFpeptides, a deep learning framework for designing high-affinity macrocyclic peptides, achieving sub-nanomolar binding affinities and accurate structural predictions.
Nature Chemical Biology · Jun 20, 2025Peer-reviewedBiochemistry