Common antigenic motif recognized by human VH5-51/VL4-1 tau antibodies with distinct functionalities
Adrian C. Apetri, Rosa Crespo, Jarek Juraszek, Gabriel Pascual, Roosmarijn Janson, Xueyong Zhu, Heng Zhang, Elissa A. Keogh, Trevin Holland, Jay Wadia, Hanneke Verveen, Berdien Siregar, Michael Mrosek, Renske L. R. E. Taggenbrock, Jeroenvan Ameijde, , Jaap Goudsmit
The paper identifies two VH5-51/VL4-1 antibodies that recognize a common tau antigenic motif and have distinct functionalities in blocking tau aggregation and mediating microglial uptake.
Acta Neuropathologica Communications · May 31, 2018Peer-reviewedNeuroscience