Author

Jay Wadia

Janssen Research & Development (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Aaron A. ThompsoniD· 1 shared Adrian C. ApetriiD· 1 shared Berdien Siregar· 1 shared Daniel Riley· 1 shared David ZuijdgeestiD· 1 shared Donata De Marco· 1 shared Elissa A. KeoghiD· 1 shared Els C. Brinkman-van der Linden· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Aaron A. ThompsonORCID

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Author profile →

2 papers

Recent·Most cited

Structures of human Malic Enzyme 3

Tsehai A.J. Grell, Mark M. Mason, Aaron A. Thompson, José Carlos Gómez-Tamayo, Daniel Riley, Michelle V. Wagner, Ruth A. Steele, Rodrigo F. Ortiz‐Meoz, Jay Wadia, Paul L. Shaffer, Gary Tresadern, Sujata Sharma, Xiaodi Yu

This study determines the structures of human Malic Enzyme 3 (ME3) in various ligand binding states, revealing its tetrameric structure and dynamic Domain C, and provides insights into its non-allosteric nature and potential for drug development.

bioRxiv · Aug 25, 2022 · PreprintMolecular Biology

Common antigenic motif recognized by human VH5-51/VL4-1 tau antibodies with distinct functionalities

Adrian C. Apetri, Rosa Crespo, Jarek Juraszek, Gabriel Pascual, Roosmarijn Janson, Xueyong Zhu, Heng Zhang, Elissa A. Keogh, Trevin Holland, Jay Wadia, Hanneke Verveen, Berdien Siregar, Michael Mrosek, Renske L. R. E. Taggenbrock, Jeroenvan Ameijde, , Jaap Goudsmit

The paper identifies two VH5-51/VL4-1 antibodies that recognize a common tau antigenic motif and have distinct functionalities in blocking tau aggregation and mediating microglial uptake.

Acta Neuropathologica Communications · May 31, 2018Peer-reviewedNeuroscience