Xueyong Zhu

This study affinity-matures an antibody to recognize both MUC1-Tn and MUC1-STn glycoforms, enhancing its efficacy against heterogeneous tumors.

This study designs stabilized HA trimers on self-assembling protein nanoparticles to improve influenza vaccine efficacy by enhancing immunogenicity and lymph node retention.

This study characterizes the structure and function of antibodies targeting the conserved β-epitope region of PfCSP, showing how they achieve strain-transcending recognition and enhance Fc-mediated immune responses.

This study identifies that H5Nx influenza A viruses bind promiscuously to avian-type mucin-like O-glycans, enhancing their zoonotic potential by binding human tracheal tissues.

This study characterizes a broad-neutralizing influenza antibody, 1122A11, showing it neutralizes multiple NA subtypes and adapts to recent glycosylation changes in H3N2 viruses.

The paper shows that a single Q226L mutation in the HA protein of a 2.3.4.4e H5 virus allows it to bind human-type receptors, unlike a modified 2.3.4.4b virus.

The paper investigates how avian H7 influenza A viruses can bind NeuGc through specific mutations, revealing insights into viral adaptation to NeuGc receptors.

The paper identifies two VH5-51/VL4-1 antibodies that recognize a common tau antigenic motif and have distinct functionalities in blocking tau aggregation and mediating microglial uptake.