UXS1 regulates UDP-GlcA levels to support growth of UGDH-high cancer cells
Yunyi Wang, Chen Zhou, Berna Bou-Tayeh, Richard Lisle, Skirmantas Kriaucionis, Yang Shi
The paper identifies UXS1 as a selectively essential gene in UGDH-high cancer cells, showing it regulates UDP-GlcA levels to prevent toxicity and highlights it as a therapeutic target.
bioRxiv · Feb 8, 2024 · PreprintCell Biology