The paper identifies UXS1 as a selectively essential gene in UGDH-high cancer cells, showing it regulates UDP-GlcA levels to prevent toxicity and highlights it as a therapeutic target.

bioRxiv · Feb 8, 2024 · PreprintCell Biology

Integrative multiomics analysis of neointima proliferation in human saphenous vein: implications for bypass graft disease

David S. Kim, Brandee M. S. S. Goo, Hong Shi, Philip Coffey, Praneet Veerapaneni, Ronnie Chouhaita, Nicole Cyriac, Ghaith Aboud, Stephen Cave, Jacob Greenway, Rohan Mundkur, Samah Ahmadieh, Ragheb Harb, Mourad Ogbi, David J. Fulton, , Neal L Weintraub

The paper analyzes multi-omics data from human saphenous veins to identify molecular and cellular changes during neointima proliferation, highlighting sex and BMI-related differences.

bioRxiv · Nov 14, 2023 · PreprintGenomics

Selective Regulation of Tuft Cell-Like Small Cell Lung Cancer by Novel Transcriptional Co-activators C11orf53 and COLCA2

Chen Zhou, Hui Huang, Yunyi Wang, Erdem Sendinc, Yang Shi

The paper identifies two understudied selectively essential genes, C11orf53 and COLCA2, as novel transcriptional co-activators in tuft cell-like SCLC, validated through computational ranking and experimental analysis.

Cell Discovery · Oct 17, 2022Peer-reviewedMolecular Biology