Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer's disease mouse model.
Ylauna Christine Mégane Penalva, Sandra Paschkowsky, Jingyun Yang, Sherilyn Junelle Recinto, Jessica K. Cinkornpumin, Marina Ruelas, Bin Xiao, Albert Nitu, Sin Young Kwon, Helen Yee-Li Wu, Hans Markus Münter, Bernadeta Michalski, Margaret L. Fahnestock, William A. Pastor, David Alan Bennett, Lisa Marie Munter
This study shows that loss of RHBDL4 in Alzheimer's disease mice increases APP and rescues cognition by reducing proteasomal degradation of β-catenin.
Cell Death and Disease · Apr 12, 2025Peer-reviewedAnimal Behavior & Cognition