Hans Markus Münter

Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer's disease mouse model.

This study shows that loss of RHBDL4 in Alzheimer's disease mice increases APP and rescues cognition by reducing proteasomal degradation of β-catenin.

Genotype imputation accuracy and the quality metrics of the minor ancestry in multi-ancestry reference panels

The paper evaluates genotype imputation accuracy in multi-ancestry reference panels and finds that the Rsq metric overestimates dosage r2 due to systematic bias in imputation quality.

Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity

The paper identifies nephronectin as a mediator of obesity's effect on COVID-19 severity using proteome-wide Mendelian randomization and validates its expression in lung cells.

Distinct pancreatic and neuronal Lung Carcinoid molecular subtypes revealed by integrative omic analysis

The paper identifies two molecular subtypes of Lung Carcinoids using integrative omic analysis and describes their distinct genetic and epigenetic features.