William A. Pastor

This study shows that phosphorylation of CARM1 at Ser572 is essential for maintaining muscle stem cell self-renewal by preventing premature myogenic commitment.

The paper shows that reducing CETP activity in Alzheimer's disease mice prevents memory decline and alters lipid and gene expression profiles, supporting CETP as a therapeutic target.

The paper investigates the roles of TRIM28, DNA methylation, and p53 in regulating gene and transposon expression in human embryonic and trophoblast stem cells, revealing divergent responses to genomic instability.

The paper shows that efferocytosis by epithelial cells during hormone deprivation in prostate cancer triggers metabolic and gene expression changes that reprogram cells for regeneration.

This study shows that loss of RHBDL4 in Alzheimer's disease mice increases APP and rescues cognition by reducing proteasomal degradation of β-catenin.

This study identifies ZMYM2 as essential for DNA methylation and silencing of germline genes and active transposons in embryonic development, revealing its role in maintaining genomic stability.

This study compares the demethylation efficacy and toxicity of GSK-3484862 and 5-azanucleosides in murine embryonic stem cells, finding GSK-3484862 induces more effective demethylation with less toxicity.

RAD identifies region-associated differentially expressed genes by linking genomic regions to gene expression changes, providing visualization and statistical analysis.