Large-Scale Comparative Transcriptomic Analysis of CHO Cell Functional Adaptation to Recombinant Monoclonal Antibody Production
Cristina N. Alexandru-Crivac, Joseph F. Cartwright, R. M. Taylor, Bernadette M. Sweeney, Marc Feary, Keerthi T. Chathoth, Daniel K. Fabian, Harry Allsopp, Adam J. Brown, David C. James
The paper compares transcriptomic changes in CHO cells producing different recombinant mAbs, finding adaptive mRNA abundance changes linked to mAb production and cellular capacity.
bioRxiv · Jun 27, 2024 · PreprintBioengineering