Author

Adam J. Brown

University of SheffieldORCID 0000-0002-3290-4560Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Bernadette M. Sweeney· 1 shared Cristina N. Alexandru-Crivac· 1 shared Daniel K. FabianiD· 1 shared David C. JamesiD· 1 shared Edward CurryiD· 1 shared Harry Allsopp· 1 shared Joseph F. Cartwright· 1 shared Keerthi T. Chathoth· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBioengineering

Bernadette M. Sweeney

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2 papers

Recent·Most cited

Synthetic G-quadruplex components for predictable, precise two-level control of mammalian recombinant protein expression

Melinda Pohle, Edward Curry, Ryan Holden, Suzanne J. Gibson, Adam J. Brown

This paper develops synthetic G-quadruplex elements to precisely control mammalian recombinant protein expression across different hosts and molecular formats.

Nucleic Acids Research · Jul 19, 2025Peer-reviewedBioengineering

Large-Scale Comparative Transcriptomic Analysis of CHO Cell Functional Adaptation to Recombinant Monoclonal Antibody Production

Cristina N. Alexandru-Crivac, Joseph F. Cartwright, R. M. Taylor, Bernadette M. Sweeney, Marc Feary, Keerthi T. Chathoth, Daniel K. Fabian, Harry Allsopp, Adam J. Brown, David C. James

The paper compares transcriptomic changes in CHO cells producing different recombinant mAbs, finding adaptive mRNA abundance changes linked to mAb production and cellular capacity.

bioRxiv · Jun 27, 2024 · PreprintBioengineering