Author

Keerthi T. Chathoth

University of Essex

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Bioengineering· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:Drosophila· 2 Organism:mouse· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Nicolae Radu ZabetiD· 2 shared Adam J. BrowniD· 1 shared Alison M. MeynertiD· 1 shared Andrew HarrisoniD· 1 shared Andrew J. WoodiD· 1 shared Bernadette M. Sweeney· 1 shared Cristina N. Alexandru-Crivac· 1 shared Daniel K. FabianiD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersGenomics

Nicolae Radu ZabetORCID

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Author profile →

4 papers

Recent·Most cited

Large-Scale Comparative Transcriptomic Analysis of CHO Cell Functional Adaptation to Recombinant Monoclonal Antibody Production

Cristina N. Alexandru-Crivac, Joseph F. Cartwright, R. M. Taylor, Bernadette M. Sweeney, Marc Feary, Keerthi T. Chathoth, Daniel K. Fabian, Harry Allsopp, Adam J. Brown, David C. James

The paper compares transcriptomic changes in CHO cells producing different recombinant mAbs, finding adaptive mRNA abundance changes linked to mAb production and cellular capacity.

bioRxiv · Jun 27, 2024 · PreprintBioengineering

The role of insulators and transcription in 3D chromatin organisation of flies

Keerthi T. Chathoth, Liudmila A Mikheeva, Gilles Crevel, Jareth C. Wolfe, Ioni Hunter, Saskia Beckett-Doyle, Sue Cotterill, Hongsheng Dai, Andrew Harrison, Nicolae Radu Zabet

This study shows that depletion of architectural proteins affects TAD organisation and gene expression in Drosophila, linking TAD reorganisation to changes in gene expression.

Genome Research · Apr 1, 2022Peer-reviewedGenomics

Chromatin architecture reorganisation during neuronal cell differentiation in Drosophila genome

Keerthi T. Chathoth, Nicolae Radu Zabet

The paper presents high-resolution contact maps of Drosophila neuronal cells and identifies TAD rearrangements during differentiation, showing enhanced long-range interactions and CTCF enrichment at cell-type-specific borders.

Genome Research · Apr 1, 2019Peer-reviewedGenomics

Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence repair outcome

Kallimasioti Pazi, Keerthi T. Chathoth, Gillian C.A. Taylor, Alison M. Meynert, Tracy J. Ballinger, Martijn J. E. Kelder, Sébastien Lalevée, Ildem Sanli, Robert Feil, Andrew J. Wood

The paper shows heterochromatin slows CRISPR-Cas9 mutagenesis but does not affect repair outcomes, with mutagenesis inhibition depending on Cas9 exposure levels.

PLoS Biology · Dec 12, 2018Peer-reviewedGenetics