Irx3/5 define the cochlear sensory domain and regulate vestibular and cochlear sensory patterning in the mammalian inner ear
Yuchen Liu, Tianli Qin, Xin Weng, Bernice Leung, Karl Kam Hei So, Boshi Wang, Wanying Feng, Alexander J Marsolais, Sheena A. Josselyn, Pingbo Huang, Bernd Fritzsch, Chi‐chung Hui, Mai Har Sham
This study shows that Irx3/5 genes are critical for patterning vestibular and cochlear sensory domains in the mammalian inner ear, with their deletion causing structural and cellular abnormalities in the cochlea.
bioRxiv · Oct 24, 2024 · PreprintDevelopmental Biology