Karl Kam Hei So

Integrative multiomic analysis on single-nucleotide variants identifies candidate genes for human craniofacial malformation

This paper identifies 249 candidate genes for human craniofacial malformation by integrating GWAS variants with epigenomic and single-cell transcriptomic data using machine learning.

Irx3/5 define the cochlear sensory domain and regulate vestibular and cochlear sensory patterning in the mammalian inner ear

This study shows that Irx3/5 genes are critical for patterning vestibular and cochlear sensory domains in the mammalian inner ear, with their deletion causing structural and cellular abnormalities in the cochlea.

seRNA PAM-1 regulates skeletal muscle satellite cell activation and aging through trans regulation of Timp2 expression synergistically with Ddx5

This study identifies PAM-1, a long non-coding RNA that regulates skeletal muscle satellite cell activation and aging by trans-regulating Timp2 expression with Ddx5.

In Vivo Study of Key Transcription Factors in Muscle Satellite Cells by CRISPR/Cas9/AAV9-sgRNA Mediated Genome Editing

This study develops a CRISPR/Cas9/AAV9-sgRNA system for in vivo genome editing in muscle satellite cells to investigate key transcription factors during activation and regeneration.