Sheena A. Josselyn

This study shows that delayed maturation of trisynaptic hippocampal circuitry is essential for the development of high-resolution episodic-like memory in mice.

The paper shows that infant-formed engrams persist as latent memories in mice and support adult learning through reactivation of dentate gyrus ensembles.

The paper shows that activity in the prelimbic cortex of developing mice promotes myelination and memory persistence, delaying infantile amnesia when inhibited.

TRACR is a transneuronal tracing system that uses synthetic Notch technology to label postsynaptic neurons and analyze circuit connectivity in the mouse visual system.

This paper introduces a brain-inspired framework for memory prioritization in neural networks based on valence, showing improved long-term memory and mitigation of the 'lost-in-the-middle' problem in language modeling.

The paper shows that distinct inputs to the CA1 region of the hippocampus support different memory resolutions by altering neural dimensionality and feedforward inhibition.

The paper shows that hippocampal memory resolution decreases over time, and this transformation depends on adult hippocampal neurogenesis.

This study shows that early-life experiences during a sensitive period influence the timing of episodic-like memory development in mice by modulating perineuronal net formation.

This study shows that Irx3/5 genes are critical for patterning vestibular and cochlear sensory domains in the mammalian inner ear, with their deletion causing structural and cellular abnormalities in the cochlea.

The paper shows that hippocampal neurogenesis remodeling causes forgetting by altering engram accessibility, using genetic and optogenetic manipulations in mice.

This study shows that the maturation of hippocampal inhibitory interneurons by extracellular matrix is necessary for the development of precise episodic-like memories in mice.

This study shows how hippocampal activity supports building predictive models by organizing newly learned information according to its congruence with existing memories.

This paper investigates whether neurogenesis acts as a regularizer in neural networks, finding it enhances generalization in a category learning task.

The paper introduces an automated curation method for CNMF-E-extracted ROIs and calcium traces using TPOT and AutoSklearn, achieving an F1 score > 92% on a test dataset.

The paper investigates how environmental enrichment affects brain volume in mice and identifies molecular processes involved, showing CREB is not required for these changes.

This paper describes the construction and use of a low-cost, open-source head-mounted endoscope for in vivo calcium imaging in freely-behaving mice.