The SERCA residue Glu340 mediates inter-domain communication that guides Ca2+ transport
Maxwell M. G. Geurts, Johannes D. Clausen, Bertrand Arnou, Cédric Montigny, Guillaume Lenoir, Robin Adam Corey, Christine Jaxel, JESPER VUUST MØLLER, Poul Nissen, Jens Peter Andersen, Marc le Maire, Maike Bublitz
The paper investigates the role of Glu340 in SERCA's inter-domain communication, showing that the E340A mutation slows Ca2+ binding kinetics and alters structural dynamics.
Proceedings of the National Academy of Sciences · Nov 23, 2020Peer-reviewedMolecular Biology