Poul Nissen

The paper reports cryo-EM structures of Na+,K+-ATPase isoforms and a disease-causing mutant, revealing conformational states and functional properties related to Na+ transport and disease mechanisms.

The paper uses expansion microscopy and cryo-electron tomography to reveal the precise spatial arrangement of AnkG and neurofascin-186 in the axon initial segment's 190-nm periodic structure.

This study uses single-molecule recordings to show Ca2+-ATPases switch between active and inactive modes, revealing a new regulatory mechanism for Ca2+ homeostasis.

The paper integrates genetic, transcriptomic, and structural data to show that Ca2+ dysregulation via ATP2B2 missense variants contributes to neuropsychiatric disorders.

The paper presents a cryo-EM structure of a Ca2+-bound intermediate in the Ca2+-ATPase 1 from Listeria monocytogenes, revealing insights into the inward-to-outward transition mechanism.

This study investigates the N-terminal regulation of ACA8 calcium pump in A. thaliana, showing that residues 20-35 and Phe32 are critical for autoinhibition and calmodulin activation.

The paper determines the structure of GlyT1 bound to an inhibitor, revealing its mechanism of non-competitive inhibition and informing drug design.

The paper investigates the role of Glu340 in SERCA's inter-domain communication, showing that the E340A mutation slows Ca2+ binding kinetics and alters structural dynamics.

The paper determines the structures of the P4-ATPase Drs2p-Cdc50p using cryo-EM, revealing autoinhibition and PI4P-dependent activation mechanisms.