Robin Adam Corey

This study identifies a novel allosteric pocket in RhoJ and shows that terconazole binds to it, disrupting its interaction with PAK3.

This study benchmarks AI-generated structural ensembles of membrane proteins against physics-based modeling, showing BioEmu can generate plausible conformations for large membrane proteins with lower computational cost.

The paper investigates alternative import pathways and destinations of PINK1 in mitochondria, revealing structural plasticity of its trans-membrane domain that influences its fate.

This study uses AI-based structural modeling to predict and compare closed-state conformations of the hERG channel, revealing insights into its dynamics and potential drug interactions.

This study determines the structure of TbAQP2 bound to drugs and glycerol, revealing how mutations in the channel lead to drug resistance in Trypanosoma brucei.

This study uses AI and simulations to analyze human rhomboid proteases, revealing that orphan members have narrower gates requiring more energy to open, explaining their substrate limitations.

This study identifies TMEM263 as an ER-resident protein essential for lipid droplet formation and growth, showing its role in lipid condensation and organismal development.

This study identifies a direct interaction between TolB and cardiolipin, revealing a lipid-binding role for TolB in maintaining outer membrane homeostasis in E. coli.

The paper investigates how cardiolipin interacts with membrane proteins to stabilize them, using a model protein and simulations to identify key factors.

This paper uses molecular dynamics simulations to show that cholesterol stabilizes M2 channel clusters, enhancing membrane curvature and promoting viral budding.

The paper develops a coarse-grained modeling approach to study Mincle receptor interactions with glycolipids, identifying key parameters like loop flexibility and calcium ion regulation.

This study identifies a new inhibited conformation of KdpFABC, termed E1-P tight, resulting from KdpBS162 phosphorylation, which represents an off-cycle state in P-type ATPases.

This study shows that NDUF-11 is essential for complex I and respiratory super-complex stability in C. elegans, affecting mitochondrial function and development.

The paper investigates the role of Glu340 in SERCA's inter-domain communication, showing that the E340A mutation slows Ca2+ binding kinetics and alters structural dynamics.