GLP-1 Notch - LAG-1 CSL control of the germline stem cell fate is mediated by transcriptional targets lst-1 and sygl-1
Jian Chen, Ariz Mohammad, Nanette J. Pazdernik, Huiyan Huang, Beth Bowman, Eric Tycksen, Tim Schedl
The paper identifies lst-1 and sygl-1 as primary transcriptional targets of GLP-1 Notch signaling in C. elegans germline stem cells, which mediate stem cell fate and inhibit differentiation.
PLoS Genetics · Mar 20, 2020Peer-reviewedDevelopmental Biology