Eric Tycksen

This study shows MANF reduces mutant uromodulin in kidney organoids by enhancing autophagy through IP3R1 repression, suggesting potential for treating ADTKD and similar protein misfolding diseases.

This study shows that synthetic oxytocin administered during postpartum hemorrhage prophylaxis in rats transfers via lactation and specifically suppresses neurodevelopmental risk gene networks in male offspring prefrontal cortex.

This study identifies de novo ATP5F1A variants causing neurological disorders through dominant negative mechanisms, expanding the known phenotypic and genotypic spectrum of complex V deficiency.

The paper examines sex biases in gene expression across brain regions and links them to sex differences in autism and Alzheimer's disease prevalence.

The paper profiles hippocampal transcriptomes across estrous cycles in mice, identifies estrous-responsive genes, and shows Cnih3 deletion disrupts estrous-specific gene expression patterns.

This study identifies itch-activated neurons in the central amygdala (CeA) and their role in itch sensation, avoidance, and comorbidities like anxiety, using RNA-sequencing and viral tracing.

The paper identifies shared and species-specific enteric neuron subtypes in humans and mice using transcriptional profiling and in situ visualization.

The paper identifies lst-1 and sygl-1 as primary transcriptional targets of GLP-1 Notch signaling in C. elegans germline stem cells, which mediate stem cell fate and inhibit differentiation.

The paper uses CRISPR TRAPseq to show QKI is important for astrocytic maturation and synaptic control in vivo.

The paper identifies an enhancer-IVL regulatory module that evolved in humans and is associated with skin barrier adaptation and atopic dermatitis risk.