Anesthesia is a Potent Determinant of Ultra-High Dose Rate Sparing in the Murine Total Abdominal Irradiation Model
Armin D. Tavakkoli, William W. Daley, David I. Hunter, Beverly A. Allen, Gretchen C. Carpenter, David J. Gladstone, Brian W. Pogue, Paul Jack Hoopes
This study shows that anesthesia type affects the effectiveness of ultra-high dose-rate FLASH irradiation in sparing normal tissue in mice, with ketamine/xylazine preserving sparing while isoflurane abolishes it.
Frontiers in Oncology · Sep 1, 2025Peer-reviewedCancer Biology