Antibiotic resistance evasion is explained by rare mutation frequency and not by lack of compensatory mechanisms
Dimitrios Evangelopoulos, Gareth A. Prosser, Angela Rodgers, Belinda M. Dagg, Bhagwati Khatri, Mei Mei Ho, Maximiliano G. Gutierrez, Teresa Cortes, Luiz Pedro S. de Carvalho
The study shows that Mycobacterium tuberculosis does not develop resistance to D-cycloserine due to its ultra-low mutation frequency, not because of a lack of compensatory mechanisms.
bioRxiv · Jul 23, 2018 · PreprintMicrobiology