Altered nuclear envelope homeostasis is a key pathogenic event in C9ORF72-linked ALS/FTD
Riccardo Sirtori, Michelle Gregoire, Alicia Collins, Serena Santangelo, Bhavya Chatragadda, Robert Cullen, Antonia Ratti, Claudia Fallini
This study identifies altered nuclear envelope homeostasis as a key pathogenic event in C9ORF72-linked ALS/FTD, showing that restoring NE tensional homeostasis can rescue NPC injury and reduce DNA damage.
bioRxiv · Feb 1, 2024 · PreprintNeuroscience