Claudia Fallini

The paper investigates synapto-nuclear signaling defects in mSOD1 mice and shows that restoring cAMP/PKA signaling mitigates pathology in motoneurons.

This study identifies LINC complex alterations as a key feature in ALS/FTD, showing their presence in both genetic and sporadic cases and their correlation with nuclear morphology changes.

This study identifies altered nuclear envelope homeostasis as a key pathogenic event in C9ORF72-linked ALS/FTD, showing that restoring NE tensional homeostasis can rescue NPC injury and reduce DNA damage.

This study shows that LSD1/KDM1A is essential for neural stem cell differentiation in mice, as its deletion causes perinatal lethality and brain defects, but motor neurons can still be generated.

This study shows that modulating actin polymerization affects nucleocytoplasmic transport in ALS, with potential therapeutic implications.

The paper shows that FUS/TLS translocates from the nucleus to the cytoplasm during excitotoxic stress via a calcium-dependent mechanism and is required for Gria2 mRNA processing.