HP1α depletion and TGFβ activation exert antagonistic effects on 3D genome organization
Fabiana Patalano, Oda Hovet, Roberto Rossini, Maxim Nekrasov, Yasmin Dijkwel, Bhumika Azad, Tatiana Soboleva, Rein Aasland, David John Tremethick, Jonas Paulsen
This study examines how HP1α depletion and TGFβ activation affect 3D genome organization in human mammary epithelial cells, revealing opposing effects on chromatin compartments and gene expression.
bioRxiv · Feb 13, 2026 · PreprintGenomics