David John Tremethick

This study examines how HP1α depletion and TGFβ activation affect 3D genome organization in human mammary epithelial cells, revealing opposing effects on chromatin compartments and gene expression.

This study investigates how 3D genome organization changes during breast cancer progression using Hi-C and epigenomic data, revealing structural alterations linked to oncogenic gene activation.

This study identifies H2A.B as a testis-specific factor that enhances ribosome biogenesis in Hodgkin Lymphoma by promoting rDNA transcription and ribosomal protein gene expression.

This study identifies POWERDRESS as a key factor for thermomorphogenesis in Arabidopsis by linking histone deacetylation to temperature-induced gene regulation.

The paper tests TALEN specificity by knocking out three H2A.B genes with a single TALEN pair, demonstrating high specificity for this multi-copy gene family.