Roberto Rossini

This study examines how HP1α depletion and TGFβ activation affect 3D genome organization in human mammary epithelial cells, revealing opposing effects on chromatin compartments and gene expression.

This study investigates how 3D genome organization changes during breast cancer progression using Hi-C and epigenomic data, revealing structural alterations linked to oncogenic gene activation.

The paper identifies germline-restricted chromosomes (GRCs) in 6,700 passerine species, showing rapid evolution and functional gene retention despite programmed DNA elimination.

StripePy is a tool for detecting architectural stripes in Hi-C data, outperforming existing methods on benchmark datasets.

hictk is a toolkit for efficiently processing .hic and .cool files, outperforming existing tools and supporting both formats natively.

MoDLE is a computational tool that rapidly simulates DNA loop extrusion contact patterns, matching existing methods and Micro-C data with high accuracy.