This study examines how HP1α depletion and TGFβ activation affect 3D genome organization in human mammary epithelial cells, revealing opposing effects on chromatin compartments and gene expression.

bioRxiv · Feb 13, 2026 · PreprintGenomics

Loss of multi-level 3D genome organization during breast cancer progression

Roberto Rossini, Mohammadsaleh Oshaghi, Maxim Nekrasov, Aurélie Bellanger, Renae Domaschenz, Yasmin Dijkwel, Mohamed Abdelhalim, Rahul Agrawal, Marit Ledsaak, Philippe Collas, Ragnhild Eskeland, David John Tremethick, Jonas Paulsen

This study investigates how 3D genome organization changes during breast cancer progression using Hi-C and epigenomic data, revealing structural alterations linked to oncogenic gene activation.

Genome Research · Oct 9, 2025Peer-reviewedGenomics

POWERDRESS-mediated histone deacetylation is essential for thermomorphogenesis in Arabidopsis thaliana

Céline Tasset, Avilash Singh Yadav, Sridevi Sureshkumar, Rupali Singh, Lennard van der Woude, Maxim Nekrasov, David John Tremethick, Martijn van Zanten, Sureshkumar Balasubramanian

This study identifies POWERDRESS as a key factor for thermomorphogenesis in Arabidopsis by linking histone deacetylation to temperature-induced gene regulation.

PLoS Genetics · Mar 16, 2018Peer-reviewedGenetics