3D human skeletal muscle organoids reveal distinct effects of high-dose dihydronicotinamide riboside on muscle development
Ashwin Venkateshvaran, Swarang Sachin Pundlik, Yavanica Suresh, Akshay Hegde, Bhushan Venkatesh, Srujanika Rajalakshmi, Sikhasmita Dowari, Alok Barik, Heera Lal, SriCharan Lakkaraju, Nikhil Zakariah, Gautham Pranesh, G. Mani Subramanian, Arvind Ramanathan
This study uses 3D human skeletal muscle organoids to show that high-dose NRH promotes early differentiation but causes structural and functional defects in muscle tissue.
bioRxiv · Dec 3, 2025 · PreprintBioengineering