This study uses Raman imaging to analyze lipid and arachidonic acid metabolism changes in MCF7 cells during doxorubicin-induced senescence, revealing metabolic remodeling and COX2-dependent AA turnover.

ACS Omega · Feb 25, 2026Peer-reviewedBiochemistry

3D human skeletal muscle organoids reveal distinct effects of high-dose dihydronicotinamide riboside on muscle development

Ashwin Venkateshvaran, Swarang Sachin Pundlik, Yavanica Suresh, Akshay Hegde, Bhushan Venkatesh, Srujanika Rajalakshmi, Sikhasmita Dowari, Alok Barik, Heera Lal, SriCharan Lakkaraju, Nikhil Zakariah, Gautham Pranesh, G. Mani Subramanian, Arvind Ramanathan

This study uses 3D human skeletal muscle organoids to show that high-dose NRH promotes early differentiation but causes structural and functional defects in muscle tissue.

bioRxiv · Dec 3, 2025 · PreprintBioengineering

Proteome plasticity in response to persistent environmental change

Matthew Domnauer, Fan Zheng, Liying Li, Yanxiao Zhang, Catherine E. Chang, Jay R. Unruh, Juliana Conkright-Fincham, Scott McCroskey, Laurence A. Florens, Ying Wen Zhang, Christopher W. Seidel, Benjamin Fong, Birgit Schilling, Rishi B. Sharma, Arvind Ramanathan, , Chuankai Zhou

This study shows that budding yeast adapts to long-term high temperature by reducing temperature-sensitive proteins, relocalizing the proteome, and altering protein conformations, which may confer new functions.

Molecular Cell · Jul 21, 2021Peer-reviewedMolecular Biology