p1/s1, a 3'-nucleotidase/nuclease, allows Leishmania major to circumvent host innate immune response mechanisms
Stella Maria Schmelzle, Michaela Bergmann, Bianca Walber, Jamal Shamsara, Tanja Ziesmann, Ute Distler, Csaba Miskey, Liam Harold Childs, Peter Kolb, Stefan Tenzer, Katrin Bagola, Ger van Zandbergen
This study identifies p1/s1, a 3'-nucleotidase/nuclease in Leishmania major, which helps the parasite evade host immune responses by generating adenosine and degrading neutrophil extracellular traps.
PLoS Pathogens · May 20, 2026Peer-reviewedImmunology