Ger van Zandbergen

This study identifies p1/s1, a 3'-nucleotidase/nuclease in Leishmania major, which helps the parasite evade host immune responses by generating adenosine and degrading neutrophil extracellular traps.

This paper develops a CRISPR base-editing library for genome-wide loss-of-function screening in Leishmania mexicana to study drug response mechanisms and identify novel biomarkers.

This study uses cryo electron tomography and simulations to analyze the structure of SARS-CoV-2 spike protein in situ, revealing three hinges in the stalk domain that enable orientational flexibility.