PGM1 deficiency disrupts sarcomere and mitochondrial function in a stem-cell cardiomyocyte model
Silvia Radenkovic, Graeme J. Preston, Rohit Budhraja, Irena Josephina Johanna Muffels, Anna N. Ligezka, Nathan P. Staff, Ron F. Hrstka, Biijina Balakrishnan, Rameen Shah, Sanne Verberkmoes, Ibrahim Shammas, Inez Bosnyák, Kyle M. Stiers, Kent Lai, Lesa J. Beamer, , Tamás Kozicz
This paper investigates the role of PGM1 in cardiomyocytes using patient-derived stem cells, finding disruptions in sarcomere and mitochondrial function, and suggesting potential therapeutic targets.
bioRxiv · Jul 1, 2025 · PreprintBiochemistry