Author

Kent Lai

University of UtahORCID 0000-0002-2377-9905Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Aaron J. Guo· 1 shared Akhilesh PandeyiD· 1 shared Anna N. LigezkaiD· 1 shared Biijina Balakrishnan· 1 shared Bijina Balakrishnan· 1 shared Éva MoravaiD· 1 shared Graeme J. PrestoniD· 1 shared Ibrahim ShammasiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetics

Aaron J. Guo

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3 papers

Recent·Most cited

AAV-based gene replacement reverses Neurexin-2 downregulation in the cerebellum of a mouse model of phosphomannomutase 2 deficiency (PMM2-CDG)

M Zhong, Kent Lai

The paper identifies Neurexin-2 downregulation in a mouse model of PMM2-CDG and shows it can be reversed by AAV9-PMM2 gene treatment.

bioRxiv · Aug 11, 2025 · PreprintGenetics

PGM1 deficiency disrupts sarcomere and mitochondrial function in a stem-cell cardiomyocyte model

Silvia Radenkovic, Graeme J. Preston, Rohit Budhraja, Irena Josephina Johanna Muffels, Anna N. Ligezka, Nathan P. Staff, Ron F. Hrstka, Biijina Balakrishnan, Rameen Shah, Sanne Verberkmoes, Ibrahim Shammas, Inez Bosnyák, Kyle M. Stiers, Kent Lai, Lesa J. Beamer, , Tamás Kozicz

This paper investigates the role of PGM1 in cardiomyocytes using patient-derived stem cells, finding disruptions in sarcomere and mitochondrial function, and suggesting potential therapeutic targets.

bioRxiv · Jul 1, 2025 · PreprintBiochemistry

Experimental galactose-1 phosphate uridylyltransferase (GALT) mRNA therapy improves motor-related phenotypes in a mouse model of Classic Galactosemia

Olivia Bellagamba, Aaron J. Guo, Xinhua Yan, Joe Sarkis, Bijina Balakrishnan, Kent Lai

This study shows that experimental GALT mRNA therapy improves motor function in a mouse model of Classic Galactosemia.

bioRxiv · Apr 21, 2025 · PreprintGenetics