Nathan P. Staff

The paper develops and validates an open-source ecosystem for implantable brain-computer interfaces and adaptive neuromodulation, demonstrating its capabilities through preclinical and human studies.

This study identifies senescent peripheral fibroblasts as the initiators of chemotherapy-induced peripheral neuropathy, showing that targeting MK2 in these cells can prevent and reverse the condition.

This study evaluates stereo EEG-based brain-computer interfacing (BCI) in adults and children, finding that overt motor BCI is more effective than imagery BCI, with performance varying by age and cortical region.

The paper investigates neuronal gene expression changes in skin biopsies from paclitaxel-induced peripheral neuropathy patients using bulk RNA sequencing and spatial transcriptomics.

This study uses cortical organoids to show that ALG13 loss-of-function causes glycosylation defects, neuronal maturation issues, and network hypoactivity in CDG.

This paper investigates the role of PGM1 in cardiomyocytes using patient-derived stem cells, finding disruptions in sarcomere and mitochondrial function, and suggesting potential therapeutic targets.

ProtPipe is a data analysis pipeline for proteomics and peptidomics that automates processing, quality control, and downstream analysis of mass spectrometry data.

The paper demonstrates the feasibility of identifying biologically active DNA aptamers that modulate the activity of human SH-SY5Y neuroblastoma cells.

The paper shows that loss of TDP-43 function leads to the expression of de novo proteins from mis-spliced mRNA transcripts in ALS/FTD.