The Alzheimer risk factor CD2AP causes dysfunction of the brain vascular network
Milène Vandal, Ádám Institóris, Ben Korin, Colin Gunn, Suzie Lee, Ji Yeon Lee, Philippe Bourassa, Ramesh C. Mishra, Govind Peringod, Yulan Jiang, Sotaro Hirai, Camille Belzil, Louise Réveret, Cyntia Tremblay, Mada Hashem, , Minh Dang Nguyen
This study shows that CD2AP loss in brain endothelial cells impairs vascular function and memory in AD models, suggesting therapeutic targeting of CD2AP pathways.
bioRxiv · Dec 10, 2020 · PreprintNeuroscience