Canonical Notch2 Signaling Regulates the Development of Iron-recycling Macrophages and Iron Homeostasis
Frauline Nicole Schroth, Tamar Kapanadze, Stefan Sablotny…·Florian P. Limbourg
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GenentechORCID 0000-0001-5685-0272Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
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Frauline Nicole Schroth, Tamar Kapanadze, Stefan Sablotny…·Florian P. Limbourg
Rojo A. Ratsimandresy, Emma Doran, Hart S. Dengler…·Mark S. Wilson
This study shows that blocking OSM and IL-6 reduces fibrosis and inflammation in pulmonary fibrosis by targeting their shared receptor and distinct pathways.
Rostislav K. Skitchenko, Zora D. Modrusan, Alexander A. Loboda…·Mykyta Artomov
The paper identifies CR1 variants as a risk factor for FSGS across diverse populations through a case-control study and variant analysis.
Martin Culka, Jonathan Desponds, Jeanne Cheung…·Darya Yu. Orlova
This paper evaluates machine learning approaches for predicting T-cell receptor specificity, highlighting limitations in current data and methods, and proposes a new framework integrating biophysical measurements.
Milène Vandal, Ádám Institóris, Ben Korin…·Minh Dang Nguyen
This study shows that CD2AP loss in brain endothelial cells impairs vascular function and memory in AD models, suggesting therapeutic targeting of CD2AP pathways.
Edward C. Stites, Andréy S. Shaw
This paper uses a computational systems pharmacology model to analyze KRAS G12C inhibitors, identifying potential strategies to improve their effectiveness and understanding resistance mechanisms.