Interneuron dysfunction in a new knock-in mouse model of SCN1A GEFS+
Antara Das, Bingyao Zhu, Yunyao Xie, Lisha Zeng, An T. Pham, Jonathan C. Neumann, Grant R. MacGregor, Soleil Sun Schutte, Robert F. Hunt, Diane K. O’Dowd
This study introduces a mouse model with a SCN1A mutation linked to GEFS+ and shows that heterozygous mutants develop seizures due to impaired inhibitory interneuron function.
bioRxiv · Nov 21, 2019 · PreprintNeuroscience