Respiratory viruses activate autophagy via the IFN-STAT1/STAT5B-SOCS1 axis
Victoria Hunszinger, Helen Dürr, Zoé Engels, Helene Hoenigsperger, Lennart Koepke, Susanne Klute, Jana-Romana Fischer, Birgit Ott, Alexander Graf, Stefan Krebs, Helmut Blum, Maximilian Hirschenberger, Frank Kirchhoff, Konstantin M. J. Sparrer
This study identifies the IFN-STAT1/STAT5B-SOCS1 axis as a mechanism by which respiratory viruses activate autophagy, showing that targeting this pathway can inhibit virus replication without compromising innate immunity.
PLoS Pathogens · Jul 15, 2026Peer-reviewedMicrobiology